Vergani Laura

Ritratto di Vergani Laura
Professore Associato, BIO/09 - Fisiologia
+39 010 353 8403
5° piano Palazzo delle Scienze ( Europa)st. V-12
Curriculum Vitae: 


1. I.M. Pepe, A. Boero, L.Vergani, I. Panfoli, C. Cugnoli "Effect of light and calcium on cyclic GMP synthesis in rod outer segments of the toad retina" Biochimica et Biophysica Acta, 889, pp. 271-276, 1986

2. I.M. Pepe, C. Cugnoli, M. Peluso, L. Vergani, A. Boero "Structure of a protein catalyzing the formation of ll-cis retinal in the visual cycle of invertebrate eyes" Cell Biophysics, 10, pp. 15-22, 1987

3. C. Nicolini, A. Diaspro, L. Vergani, M. Bertolotto, P. Germano "Nuclear architecture and intranuclear DNA distribution nuclease digestion" Cell Biophysics, 13, 1, pp. 1-12, 1988

4. C. Nicolini, A. Diaspro, L. Vergani, G. Cittadini "In situ thermodynamic characterization of chromatin and of other cell macromolecules during cell cycle" International Journal Biological Macromolecules, 10, 3, pp. 137-144, 1988

5. C. Nicolini, L. Vergani L., A. Diaspro A., P. Scelza "Native chromatin and damage induced by nuclease" Biochemical and Biophysical Research Communications, 155, 3, pp. 1396- 1403, 1988

6. C. Nicolini, L. Vergani, A. Diaspro, E. Di Maria "Native chromatin-DNA structure and cell-cycle: differential scanning calorimetry and gel electrophoresis" Thermochimica Acta, 152, pp. 307-327, 1989
7. C. Nicolini, L. Vergani, A. Diaspro, P. Scelza "The true native chromatin-DNA structure and its role in the control of gene expression" in Macromolecules in the Functioning Cell (Eds. A.A. Bayev, A.D. Mizrzabekov, M.Y Timofeeva), Academy of Sciences, Pushchino Research Centre, 1991., vol. 6, pp. 15-31, 1991 (ISBN: 9785201105600)
8. C. Nicolini and L. Vergani “Possible effects of a geophysical variable on nuclear DNA structure and function” in: Progress in Biometereology: effects of atmospheric and geophysical variables in biology and medicine, (ed. H. Lieth), SPB Academic Publishing, Hague (Netherlands), vol. 8, pp. 150-158, 1991 (ISBN: 90 5103 061 4)

9. A. Diaspro, M. Bertolotto, L. Vergani, C. Nicolini "Polarized Light Scattering of Nucleosomes and polynucleosomes: in situ and in vitro studies" IEEE Transactions on Biomedical Engineering, 38, 7, pp. 670-678, 1991

10. C. Nicolini, A. Diaspro, M. Bertolotto, P. Facci and L. Vergani "Changes in DNA superhelical density monitored by polarized light scattering" Biochemical & Biophysical Research Communcations, 177, 3, pp. 1313-1318, 1991

11. L. Vergani, Gavazzo P., Mascetti G.C. and Nicolini C. "Effects of fixatives on high order chromatin structure; a calorimetric study" Thermochimica Acta, 206, pp. 175-179, 1992

12. L. Vergani, Gavazzo P., Facci P., A. Diaspro, Mascetti G., Arena N., L. Gaspa and Nicolini C. "Fluorescence cytometry of microtubules and nuclear DNA during cell-cycle and reverse transformation" Journal of Cellular Biochemistry, 50, pp. 201-209, 1992

13. L. Vergani, Gavazzo P., Mascetti G. and Nicolini C. "Ethidium Bromide intercalation and chromatin structure: a spectropolarimetric analysis" Biochemistry-US, 33, pp. 6578-6585, 1994

14. G. Mascetti, L. Vergani, A. Diaspro, S. Carrara, G. Radicchi, C. Nicolini "Effects of fixatives on calf thymocytes chromatin: 3D High Resolution Fluorescence Microscopy", Cytometry, 23, 2, pp. 110-125, 1996

15. P. Gavazzo, L. Vergani, G. Mascetti, C. Nicolini. "Effects of Histone acetylations on higher order chromatin structure and function", Journal of Cellular Biochemistry, 64, 3, pp. 466-475, 1997

16. L. Vergani, Mascetti G., Gavazzo P. and Nicolini C. "Ethidium Bromide intercalation and chromatin structure: a thermal analysis", Thermochimica Acta, 294, pp. 193-204, 1997

17. E. Maccioni, L. Vergani, A. Dembo, G. Mascetti, C. Nicolini "An X-ray small angle scattering study of chromatin as a function of fiber length" Molecular Biology Reports, 25, 2, pp. 73-86, 1998

18. L. Vergani, Mascetti G. and Nicolini C. "Effects of polyamines on higher-order folding of in situ chromatin" Molecular Biology Reports, 25, 4, pp. 237-244, 1998

19. L. Vergani., Fugazza G., Chessa L and Nicolini C. "Changes of chromatin condensation in Ataxia telangiectasia disorder: a structural study" Journal of Cellular Biochemistry, 75, 4, pp. 578-586, 1999

20. L. Vergani, Mascetti G.and Nicolini C. "Changes of in situ chromatin structure and organization induced by increasing temperature" Journal of Biomolecular Structure and Dynamics vol 18, issue 4, pp. 535-544 2001

21. G. Mascetti, Carrara S. and L. Vergani "Relationship between fiber folding and dye uptake for in situ chromatin stained with a DNA-selective dye" Cytometry 44, 2, pp. 113-119, June, 2001

22. L. Vergani, Caneva F., Ghisellini P. and Nicolini C., “Expression, purification and structural characterization of human histone H4” Protein Expression and Purification vol. 24, issue 3, pp.420-428, April 2002

23. B. Spadiliero, Nicolini C., Mascetti G., Henriquez D. and Vergani L., “Chromatin of Trypanosoma cruzi: in situ analysis revealed its unusual structure and nuclear organization” Journal of Cellular Biochemistry, 85, pp. 798-808, 2002

24. L. Vergani, Grattarola M., Dondero F. and Viarengo A., “Expression, purification and characterization of metallothionein A from rainbow trout” Protein Expression and Purification Feb,27(2), pp. 338-34, 2003

25. L. Emionite, F. Galmozzi, P. Raffo, L. Vergani and S. Toma ‘Retinoids and Malignant Melanoma: a Pathway of Proliferation inhibition on SK MEL28 cell line” Anticancer Research 23, pp. 13-20, 2003

26. E. Grasselli, G. Noviello, C. Rando, C. Nicolini and L. Vergani ‘Expression, purification and characterization of a novel mutant of the human protein kinase CK2’ Molecular Biology Reports June,2 (30), pp. 97-106, 2003

27. S. Toma, Emionite L., Galmozzi F., Spadini N. and L. Vergani ‘Chemoprevention of tumors: the role of RAR-beta’ International Journal of Biological Markers Jan-Mar;18(1), pp. 78-81, 2003

28. E. Pulsinelli, Vasile F., Vergani L., Parodi S. and Nicolini C. “Structural characterization of Int and Int-H1 peptides by Circular Dichroism and NMR spectroscopy” Protein and Peptide Letters Dec,10(6)541-549 2003

29. M. Grattarola, S. Spaggiari, L. Chessa, C. Savio, C. Nicolini and L. Vergani “A structural characterization of in situ chromatin on cell lines isolated from patients affected by Ataxia Telangiectasia” International Journal of Biological Macromolecules Nov 33,1(3), pp. 23-29, 2003

30. E. Grasselli, V. Tomati, M. Berbasconi, C. Nicolini and L. Vergani “C terminal region of protein kinase CK2: how the structure can affect function and stability of the catalytic subunit” Journal of Cellular Biochemistry May,15, 92(2), pp. 270-284, 2004

31. L. Vergani, M. Grattarola and C. Nicolini “Modifications of chromatin structure and gene expression induced alterations of cellular shape” The International Journal of Biochemistry & Cell Biology 36(8), pp. 1447-1461, 2004

32. L. Emionite, F. Galmozzi, M. Grattarola, F. Boccardo, L. Vergani and S. Toma “Histone Deacetylase Inhibitors enhance retinoid response in human breast cancer cell lines” Anticancer Research Nov-Dec, 24(6), pp.4019-4024, 2004
33. L. Vergani, M. Grattarola, C. Borghi, F. Dondero and A. Viarengo “Fish and molluscan metallothioneins: structural and functional comparison” The FEBS Journal (European Journal of Biochemistry), Dec,272(23), pp. 6014-6023, 2005

34. F. Dondero, L. Piacentini, F. Marsano, M. Rebelo, L. Vergani, P. Venier, A.Viarengo “Gene transcription profiling in pollutant exposed mussels (Mytilus spp.) using a new low-density oligonucleotide microarray” Gene July,5;376(1), pp. 24-36, 2006

35. M. Grattarola, C. Borghi, L. Emionite, P. Lulli, L. Chessa and L.Vergani “Modifications of nuclear architecture and chromatin organization in ataxia telangiectasia cells are coupled to changes of gene transcription” Journal of Cellular Biochemistry Nov,1;99(4), pp. 1148-64, 2006

36. M. Grattarola, M. Carloni, F. Dondero, A. Viarengo and L. Vergani “Expression, purification and preliminary characterization of mussel Mytilus galloprovincialis metallothionein MT20” Molecular Biology Reports, Dec,33(4), pp. 265-72, 2006

37. L. Vergani, C. Lanza, C.Borghi, L. Scarabelli, I. Panfoli, B. Burlando, A. Viarengo, G. Gallo "Effects of growth hormone and cadmium on the transcription regulation of two metallothionein isoforms” Molecular and Cellular Endocrinology, Jan,15;263(1-2), pp. 29-37, 2007

38. L. Canesi, C. Borghi, R. Fabbri, C. Ciacci, L. C. Lorusso, G. Gallo and L. Vergani, “Effects of 17β-estradiol on mussel digestive gland”. General & Comparative Endocrinology, Aug-Sep;153(1-3), pp.40-6, 2007

39. L. Vergani, M. Grattarola, E. Grassell, F. Dondero and A. Viarengo “Molecular characterization and function analysis of MT-10 and MT-20 metallothionein isoforms from Mytilus galloprovincialis” Archives of Biochemistry and Biophysics, Sep,1;465(1), pp. 47-53, 2007

40. L. Canesi, C. Borghi, C. Ciacci, R. Fabbri, L. Vergani and G. Gallo “Bisphenol A alters gene expression and functional parameters in molluscan hepatopancreas” Molecular and Cellular Endocrinology, Sep 30;276(1-2), pp. 36-44, 2007

41. E. Grasselli, L. Canesi, A. Voci, I. Demori, E. Fugassa, R. De Matteis and L. Vergani "Effects of 3,5-diiodo-L-thyronine administration on the liver of high-fat diet fed rats" Experimental Biology and Medicine May,233(5), pp. 549-57, 2008

42. A. Buico, C. Cassino, F. Dondero, L. Vergani , D. Osella ‘Radical scavenging abilities of fish MT-A and mussel MT-10 metallothionein isoforms: an ESR Study’ Journal of Inorganic Biochemistry Apr,102(4), pp. 921-7, 2008

43. L. Canesi, C. Borghi, C. Ciacci, R. Fabbri,LC Lorusso, L. Vergani, A. Marcomini, G. Poiana “Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland” Aquatic Toxicology May,30;87(4), pp. 272-9, 2008
44. L. Vergani “Metallothioneins in aquatic organisms: fish, crustaceans, molluscs and echinoderms” in the series Metal ions in life sciences Vol 5 “Metallothioneins and Related Chelators” (eds A. Sigel, H. Sigel, and R.K.O. Sigel), Royal Society of Chemistry Publishing, Cambridge, UK, pp. 199-233, 2009 (ISBN: 978-1-84755-899-2)

45. G. Digilio, o C. Bracc, L. Vergani, M. Botta, D. Osella, A. Viarengo “The cadmium binding domains in the metallothionein isoform Cd7-MT10 from Mytilus galloprovincialis revealed by NMR spectroscopy” Journal of Biological Inorganic Chemistry Feb;14(2), pp. 167-78, 2009

46. L. Vergani, C. Lanza, L. Scarabelli, L. Canesi, G. Gallo “Heavy metal and growth hormone pathways in metallothionein regulation” Comparative Biochemistry and Physiology, C Toxicol Pharmacol May;149(4), pp. 572-80, 2009

47. D. Calzia, I. Panfoli, S. Ravera, E. Dazzi, S. Gandolfo, IM Pepe, L. Vergani, AM Morelli "Structural modification of proteins by direct electric current from low voltage" Journal of Biochemical & Molecular Toxicology Sep;23(5), pp. 309-17, 2009

48. C. Lanza., S. Morando., A. Voci., L. Canesi., C. Principato., G. Mancardi., A. Uccelli. and L. Vergani. "Neuroprotective Mesenchymal Stem Cells exert a potent antioxidant effect in vivo" Journal of Neurochemistry Sep;110(5), pp. 1674-84, 2009

49. E. Grasselli, A. Voci, C. Pesce, L. Canesi, E. Fugassa, G. Gallo. and L. Vergani “PAT protein mRNA expression in primary rat hepatocytes: effects of exposure to fatty acids” International Journal of Molecular Medicine Apr;25(4), pp. 505-12, 2010

50. L. Canesi, C. Barmo, R. Fabbri, C. Ciacci, L. Vergani, P. Roch, G. Gallo “Effects of vibrio challenge on digestive gland biomarkers and antioxidant gene expression in Mytilus galloprovincialis” Comp Biochem Physiol C Toxicol Pharmacol. Sep;152(3), pp. 399-406, 2010

51. E. Grasselli, A. Voci, L. Canesi, F. Goglia, S. Ravera, I. Panfoli, G. Gallo and L Vergani “Non-receptor mediated actions are responsible for the lipid-lowering effects of iodothyronines in FaO rat hepatoma cells” Journal of Endocrinology Jul;210(1), pp. 59-69, 2011 (DOI: 10.1530/JOE-11-0074)

52. L. Vergani, C. Lanza, P. Rivaro, M. Abelmoschi, S. Genti, E. Veneselli, G. Minniti, E. Grasselli, L. Canesi, A. Voci “Metals, metallothioneins and oxidative stress in blood of autistic children” Research in Autism Spectrum Disorders 5 (1), pp. 286-293, 2011 (DOI 10.1016/j.rasd.2010.04.010)

53. E. Grasselli, A. Voci, L. Canesi, R. De Matteis, F. Golgia, F. Cioffi, E. Fugassa G. Gallo and L. Vergani “Direct effects of 3,5- diiodo-L-thyronine (T2) on fat accumulation in primary cultures of rat hepatocytes” Journal of Hepatology Jun;54(6), pp. 1230-6, 2011 (DOI: 10.1016/j.jhep.2010.09.027)

54. E. Grasselli, A. Voci, I. Demori, L. Canesi, R. De Matteis, F. Goglia, A. Lanni, G. Gallo and L. Vergani “3,5-diiodo-L-thyronine (T2) modulates the expression of genes of lipid metabolism in a rat model of fatty liver” Journal of Endocrinology 2012 Feb;212(2), pp. 149-58, 2012

55. C. Lanza, S. Raimondo, L. Vergani, N. Catena, F. Sénès, P. Tos, S. Geuna “Expression of antioxidant molecules after peripheral nerve injury and regeneration.” Journal of Neuroscience Research Apr;90(4), pp. 842-8, 2012 (DOI: 10.1002/jnr.22778)

56. A. Uccelli, M. Milanese, MC. Principato, S. Morando, Bonifacino T., L. Vergani, D. Giunti, A. Voci, E. Carminati, F. Giribaldi, C. Caponnetto and GB Bonanno “Intravenous Mesenchymal Stem Cells Improve Survival and Motor Function in Experimental Amyotrophic Lateral Sclerosis” Molecular Medicine, Jul;18; pp.794-80 2012 (DOI: 10.2119/molmed.2011.00498)

57. D. Giunti, B. Parodi, C. Usai, L. Vergani, S. Casazza, S. Bruzzone, G. Mancardi, A.Uccelli “Mesenchymal Stem Cells Shape Microglia Effector Functions Through the Release of CX3CL1” Stem Cells Sep;30(9), pp. 2044-53, 2012 (DOI: 10.1002/stem.1174)

58. G. Minniti, R. Lorini, E Veneselli, L. Vergani, A. Voci, MG Calevo, FM. Battaglia “Are psychobiological markers strongly correlated with allostatic load in population with autism spectrum disorders (ASD)?” Med Hypotheses Apr;80(4), pp. 506-8 2013 (DOI: 10.1016/j.mehy.2012.12.011)

59. E. Grasselli, K. Cortese, A. Voci, L. Vergani, R. Fabbri., C. Barmo, G. Gallo, L. Canesi “Direct effects of Bisphenol A on lipid homeostasis in rat hepatoma cells” Chemosphere May;91(8), pp. 1123-9 2013 (DOI: 10.1016/j.chemosphere.2013.01.016)

60. M. Milanese, F. Giribaldi, M. Melone, T. Bonifacino, I. Musante, E. Carminati, P.I.A. Rossi, L. Vergani, A. Voci, F. Conti, A. Puliti, G. Bonanno “Knocking-down metabotropic glutamate 1 receptor improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis” Neurobiology of Disease April;64, pp. 48–59 2014 (DOI: 10.1016/j.nbd.2013.11.006)

61. E. Grasselli, A. Voci, I. Demori, R. De Matteis, A. Compalati, G. Gallo and L. Vergani “Effects of binge ethanol administration on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease (NAFLD)” Journal of Physiology & Biochemistry, Jun;70(2), pp:341-53. 2014 (DOI: 10.1007/s13105-013-0308-x)

62. E. Grasselli, A. A. Voci, L. Canesi, A. Salis, G. Damonte, A. Compalati, F. Goglia, G. Gallo and L. Vergani “3,5-Diiodothyronine modifies the lipid droplet composition in a model of hepatosteatosis” Cellular Physiology & Biochemistry 33(2), pp.344-56 2014 (DOI: 10.1159/000356674)

63. L. Vergani “The lipid lowering effects of iodothyronines: in vivo and in vitro studies on rat liver " World Journal of Hepatology Apr 27;6(4) pp.169-177 2014 (DOI: 10.4254/wjh.v6.i4.169)

64. E. Grasselli, K. Cortese, R. Fabbri, A. Smerilli, L. Vergani, A. Voci, .G. Gallo and L. Canesi “Thyromimetic actions of Tetrabromobisphenol A (TBBPA) in steatotic FaO rat hepatoma cells” Chemosphere Oct; pp. 112511-518 2014 (DOI: 10.1016/j.chemosphere.2014.03.114)

65. E. Grasselli, A. Compalati, A. Voci, .G. Vecchione, M. Ragazzoni, G. Gallo, P. Borro, A. Sumberaz, G. Testino and L. Vergani “Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease” Drug and Alcohol Dependence Oct 1;143 pp. 112-9. 2014 (DOI: 10.1016/j.drugalcdep.2014.07.013)

66. F. Benvenuto, A. Voci, E. Carminati,, F. Gualandi, G. Mancardi, A. Uccelli and L. Vergani “The immunosuppressive effects of human mesenchymal stem cells target adhesion molecules and receptors involved in T cell extravasation” Stem Cell Research and Therapy December 10;6(1):245, 2015 (DOI: 10.1186/s13287-0xx-0228-5.)

67. M. Pintaudi, E. Veneselli, A. Voci, A. Vignoli, D. Castiglione, MG. Calevo, E. Grasselli, M. Ragazzoni, F. Cogliati, L. Calzari, GF. Scornavacca, S. Russo and L. Vergani “Blood oxidative stress and metallothionein expression in Rett syndrome: probing for markers” The World Journal of Biological Psychiatry Oct 15: pp. 1-12, 2016 (ID: 1077990 DOI:10.3109/15622975.2015.1077990)

68. C. Cervetto, L. Vergani, M. Passalacqua, M. Ragazzoni, A. Venturini, F. Cecconi, N. Berretta, N. Mercuri, M. D’Amelio, G. Maura, P. Mariottini, A. Voci, M. Marcoli, M. Cervelli “Astrocyte-dependent vulnerability to excitotoxicity in spermine oxidase overexpressing mouse” NeuroMolecular Medicine Mar;18(1): pp. 50-68, 2016 (DOI:10.1007/s12017-015-8377-3. Epub 2015 Nov 3)

69. E. Grasselli, I. Demori, G. Vecchione, A. Compalati, G. Gallo, R. De Matteis, E. Silvestri, F. Goglia, A. Voci and Vergani L “Effects of iodothyronines on lipid mobilization and mitochondrial oxidation in cultured steatotic hepatocytes” Frontiers in Physiology Jan; 12; 6:418, pp. 1-10, 2016 (DOI: 10.3389/fphys.2015.00418)

70. G. Vecchione, E. Grasselli, A.D. Compalati, M. Ragazzoni, K. Cortese, G. Gallo, A. Voci a and L. Vergani. “Ethanol impairs lipid homeostasis in an in vitro model of hepatic steatosis” Food and Chemical Toxicology Apr; 90, pp. 84-94, 2016 (DOI:10.1016/j.fct.2016.02.004)

71. L. Vergani, G. Vecchione, F. Baldini, A. Voci, P.F. Ferrari, B. Aliakbarian, A. Casazza, P. Perego. “Antioxidant and Hepatoprotective Potentials of Phenolic Compounds from Olive Pomace” Chemical Engineering Transactions 49, pp. 474-480, 2016 (DOI: 10.3303/CET1649080) (ISBN 978-88-95608-47-1)
72. G. Vecchione, E. Grasselli,, A. Voci, F. Baldini, I. Grattagliano, D.Q.H. Wang, P. Portincasa and L. Vergani. “Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells” World Journal of Gastroenterology July; 14; 22(26); pp. 6016-6026, 2016 2 (DOI: 10.3748/wjg.v22.i26.6016)

73. M. Pozzolini, L. Vergani, M. Ragazzoni, L. Delpiano, E. Grasselli, A. Voci, M. Giovine, S. Scarfì. “Different reactivity of primary fibroblasts and endothelial cells towards crystalline silica: a surface radical matter” Toxicology Jun 15; 361-362: pp. 12-23, 2016 (DOI: 10.1016/j.tox.2016.07.001)

74. L. Vergani ”Fatty acids and effects on in vitro and in vivo models of liver steatosis” Current Medicinal Chemistry May-17 pp. 2017 (DOI: 10.2174/0929867324666170518101334)

75. Grattagliano I, Oliveira PJ, Vergani L, Portincasa P “Oxidative and nitrosative stress in chronic cholestasis” in Liver Pathophysiology: Therapies and Antioxidants (Pablo Muriel ed.) Academic Press 2017 (ISBN: 9780128042748)

76. Vergani L, Vecchione G, Baldini F, Grasselli E, Voci A, Portincasa P, Ferrari PF, Aliakbarianc B, Casazza A, Perego P. “Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells” European Journal of Nutrition May-19 pp. 11-13 2017 (DOI: 10.1007/s00394-017-1464-5)

77. Grasselli E, Canesi L., Voci A, Portincasa P, Vergani L, Demori I, “Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine” Annals of Hepatology 2017 Sep-Oct; 16(5):707-719. DOI: 10.5604/01.3001.0010.2713)

78. Vecchione G, Grasselli E, Cioffi F, Baldini F, Oliveira PJ, Sardão VA, Cortese K, Lanni A, Voci A, Portincasa P and Vergani L “The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression” Front Nutr. 2017 Sep 19;4:42. (DOI: 10.3389/fnut.2017.00042)

79. Amaroli A, Ravera S, Baldini F, Benedicenti S, Panfoli I and Vergani L “Photobiomodulation with 808-nm diode laser light promotes wound healing of human endothelial cells through increased reactive oxygen species production stimulating mitochondrial oxidative phosphorylation” Lasers in Medical Science. 2018 In press